Patient Derived Tumor Xenograft Models: Promise, Potential and Practice

Patient Derived Tumor Xenograft Models

A comprehensive reference on patient-derived tumor xenograft (PDX) models, covering their development, application, and use in cancer research. It provides practical guidance on model selection, tumor growth, pathology and genomic analysis, data interpretation, laboratory requirements, and regulatory considerations.

Key Features:

• Explains the principles and applications of PDX models
• Provides guidance on PDX modeling and experimental studies
• Covers selection of appropriate immunodeficient animal strains
• Discusses methods for growing different tumor types
• Covers pathology and genomic characterization
• Explores data collection and interpretation
• Identifies common pitfalls and confounding pathologies
• Discusses facilities and infrastructure for PDX laboratories
• Covers regulatory considerations and best practices
• Includes practical techniques and research strategies
• Presents findings from a global survey of PDX standards and practices
• Useful for cancer researchers, biomedical scientists, laboratory professionals, and students