X Mitochondrial Transplantation and Transfer Biology, Methods, Applications, and Disease

Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, part of the Translational and Applied Bioenergetics series, delivers a groundbreaking and comprehensive examination of the emerging field of mitochondrial therapy. With contributions from over twenty leading researchers, this volume explores the biological principles, technical methodologies, and clinical potential of mitochondrial transplantation as a novel therapeutic approach.

This reference provides in-depth coverage of mitochondrial physiology, isolation, and transfer techniques, as well as their application in a wide array of disease contexts—including cardiovascular, neurological, and metabolic disorders. It bridges the gap between experimental bioenergetics and clinical innovation by offering detailed protocols, translational strategies, and ethical considerations essential to this rapidly evolving domain. Ideal for researchers, clinicians, and biotechnologists, this book equips professionals with both the scientific foundation and the practical tools needed to advance mitochondrial therapies.

Key Features:

• Comprehensive Scope: Covers the full continuum from basic mitochondrial biology to clinical applications, focusing on both natural and engineered mitochondrial transfer.

• Disease-Focused Applications: Highlights therapeutic potential across diverse conditions such as ischemic heart disease, neurodegenerative disorders, diabetes, and mitochondrial myopathies.

• Step-by-Step Protocols: Includes detailed, reproducible laboratory methods for mitochondrial isolation, labeling, transplantation, and assessment of functional outcomes.

• Innovative Techniques: Discusses cutting-edge transfer strategies, including microinjection, cell-to-cell transfer, extracellular vesicle-mediated delivery, and systemic infusion.

• Ethical Considerations: Provides thoughtful analysis of ethical, regulatory, and safety issues related to mitochondrial manipulation and therapeutic use, particularly in germline and pediatric applications.

• Translational Emphasis: Focuses on bench-to-bedside development of mitochondrial therapies, with insights into preclinical models, biomarkers, delivery challenges, and clinical trial readiness.

• Expert Contributions: Features authoritative content from leading scientists and clinicians in bioenergetics, regenerative medicine, and mitochondrial biology.

• Series Integration: Part of the Translational and Applied Bioenergetics series, ensuring continuity and depth across topics in energy metabolism and biomedical applications.