GABAB Receptor

Master GABA B Receptor Pharmacology: Translating Receptor Science into Therapeutic Impact

Dive into a fully updated and authoritative overview of the GABA_B receptor system and its expanding role in neuropharmacology. This second edition blends molecular biology, physiology, medicinal chemistry, and clinical trials to deliver a translation-focused exploration of GABA_B signaling.

Key Features:

Mechanistic & Molecular Insight: Covers receptor structure and protein‑protein interactions, allosteric modulation, and detailed molecular pharmacology to explain ligand mechanisms and receptor regulation.
Clinical Relevance of Baclofen: Presents both the history and current clinical applications of baclofen—its use in treating spasticity, dystonia, chronic cough, alcohol use disorder, and its safety, withdrawal profiles, and overdose management.
Advances in Drug Discovery: Highlights breakthroughs in positive allosteric modulator (PAM) design and preclinical pharmacology aimed at new treatment approaches for neuropsychiatric disorders, substance abuse, and food addiction.
Emerging Therapeutic Scope: Explores GABA_B receptor involvement beyond neurology—in gastrointestinal reflux disease, mood disorders, epilepsy, depression, addiction, and related pathologies.
Translational Perspective: Frames bench-to-bedside translation through chapters on novel ligands, ligand screening, biomarker development, and strategies for therapeutic validation across disease models.

Edited by a leading authority in receptor neuroscience, this volume is ideal for neurobiologists, neuropharmacologists, medicinal chemists, neuroscientists, and clinician-researchers focused on receptor-targeted innovation. Whether you’re developing new ligands, designing translational studies, or interpreting clinical pharmacology data, this book serves as a comprehensive reference to drive receptor-based therapeutic strategies forward.