Childhood Stress, Trauma and Synapse Loss

Master BDNF Science: Illuminating the Role of a Key Neurotrophin in Brain Development and Repair

Delve into the definitive second edition that merges molecular, cellular, and translational science surrounding Brain-Derived Neurotrophic Factor (BDNF). This comprehensive resource presents foundational understanding alongside the latest advances in BDNF’s role in neuroplasticity, development, and neurological disorders.

Key Features:

Molecular Mechanisms & Genetic Insights: Explores BDNF gene regulation, signaling pathways (e.g. TrkB), epigenetic control, and the impact of genetic variants across developmental stages and disease contexts.
Developmental & Lifespan Relevance: Covers BDNF’s influence on neuronal growth, synaptic formation, adolescent maturation, and aging-related decline—highlighting its role across the entire lifespan.
BDNF in Health and Disease: Analyzes its functions in learning, memory, mood regulation, neurogenesis, and neurocircuit maintenance, alongside involvement in conditions such as depression, Alzheimer's, Parkinson’s, schizophrenia, and stroke recovery.
Therapeutic Targeting: Profiles cutting-edge approaches including peptide mimetics, small-molecule TrkB agonists, gene therapy, exercise-induced modulation, and lifestyle interventions to enhance BDNF function and brain resilience.
Translation & Clinical Trials: Focuses on biomarker development, pharmacological modulation in human populations, trials of BDNF-based therapies, and predictive modeling—bridging preclinical promise with clinical applicability.

Ideal for neuroscientists, neuropharmacologists, clinicians, translational researchers, and mental health professionals, this volume offers both depth and clarity in BDNF research and application. Whether studying neural development, designing neuroprotective interventions, or improving recovery after injury, this book equips you with the tools to translate BDNF science into measurable brain health outcomes.