X Biomarkers in Kidney Transplantation Clinical Aspects and Laboratory Determination

Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination is a specialized, authoritative reference that offers a comprehensive examination of both established and emerging biomarkers used to predict, diagnose, and monitor kidney transplant rejection. With a unique integration of clinical and laboratory perspectives, the book delivers critical insights into biomarker utility across various types of rejection—acute, chronic, T-cell mediated, antibody mediated, and mixed forms—helping clinicians and laboratorians alike make informed therapeutic decisions.

This volume also provides an in-depth analysis of the biomarker discovery pipeline, validation protocols, and analytical challenges faced in clinical laboratory settings. It bridges the gap between biomolecular research and clinical application by categorizing biomarkers based on function—diagnostic, prognostic, predictive, susceptibility, and monitoring—and by addressing both pharmacodynamic and pharmacokinetic markers. As a consolidated, up-to-date resource, it is ideal for transplant clinicians, immunologists, pathologists, pharmacologists, and lab professionals seeking precision-guided transplant care.

Key Features:

• Complete Biomarker Overview: Comprehensive coverage of all current and emerging biomarkers relevant to kidney transplant outcomes, organized by type of rejection and clinical purpose.

• Functional Classification: Differentiates between pharmacokinetic and pharmacodynamic biomarkers and classifies them by role (e.g., diagnostic, predictive, prognostic, monitoring, susceptibility).

• Clinical and Laboratory Integration: Merges practical clinical applications with in-depth laboratory processes, including biomarker discovery, measurement techniques, and validation challenges.

• Analytical Guidance: Discusses laboratory standards, pitfalls in biomarker quantification, assay sensitivity, and reproducibility, helping ensure accurate implementation in clinical practice.

• Case-Based Context: Includes real-world examples and interpretation strategies for using biomarkers to guide immunosuppression, detect early signs of rejection, and monitor long-term graft health.

• Multidisciplinary Utility: Designed for a wide audience including transplant nephrologists, surgeons, pathologists, clinical pharmacologists, immunologists, and laboratory scientists.

• Up-to-Date and Evidence-Based: Reflects the latest research findings, consensus guidelines, and clinical trial data related to biomarker utility in transplantation medicine.