Basic Principles of Drug Discovery and Development

Drug Discovery and Development

Basic Principles of Drug Discovery and Development by Benjamin E. Blass provides a comprehensive introduction to the scientific and practical processes involved in developing new medicines. It explores key techniques in drug discovery, medicinal chemistry, pharmacology, drug metabolism, toxicology, and clinical research. This updated edition also covers biologics, modern drug delivery systems, computational methods, and selected business aspects of pharmaceutical development.

Key Features:

• Explains the complete drug discovery and development process, from identifying promising compounds to producing new medicines.
• Introduces important drug targets and their roles in therapeutic development.
• Covers in vitro screening methods used to evaluate potential drug candidates.
• Explores medicinal chemistry strategies and structure-based drug design.
• Explains pharmacokinetics and pharmacodynamics in drug research.
• Discusses animal models used to investigate disease states and evaluate potential treatments.
• Introduces clinical trial fundamentals and the progression of drugs toward clinical use.
• Includes a new chapter on biologics, including antibodies, proteins, and antibody–drug conjugates.
• Covers pharmaceutical formulations, nanotechnology, intravenous formulations, and transdermal drug delivery.
• Features updated case studies on high-throughput screening, fragment-based drug design, and computational chemistry.